Activioss Slide 1 Activioss Slide 2 Activioss Slide 4 Activioss Slide 6 Activioss Slide 7

Product



Functional and aesthetic restoration are daily challenges for dental surgeons. The choice of treatment and implants and high performance bone substitutes are the answer to the specificity of clinical cases.

Activioss™ is indicated in regenerative medicine. It combines natural biological action and optimum safety for reliable and reproducible results.

Activioss™ is a synthetic, bioactive bone substitute which comes in the form of granules.

Based on innovative technology, Activioss™ is a Bioactive Glass 45S5 ceramic composed of silicium, sodium, phosphorus and calcium oxide. All of these elements are naturally present in the human body and are crucial agents in the osteogenesis process. This bioactivity, marks a new stage in bone regeneration products.

The mineral ion formula of Activioss™ increases its biocompatibility and removes the risk of transmitting pathogens. The bone regeneration product Activioss™ comes from a technology developed in France with local partners to ensure highest quality.

Activioss™ offers dentists and patients optimum safety during implantation for natural, effective bone restoration for all indication encountered in daily dental practice.





Activioss™ Granule, medical device class III, manufactured by Noraker, CE Mark n° (0459). Activioss™ Granule is a biomaterial of bone substitution, indicated in bone defect filling. Read the instructions supplied with the product for complete information.
Packaging Activioss

Bioactive

Osteostimulative

Hydrophilic

Volume Preservation

Synthetic

Antibacterial

DOCUMENTATION
AVAILABLE
GALLERY
Activioss 1
Activioss 2 Activioss 3

Bioactive


Stimules osteogenesis

Activioss™ has a higher degree of bioactivity.


Natural bone remodelling of the patient is the major factor in dental implant osteointegration. Bioactivity of Activioss™ ensures natural bone remodelling in two crucial stages: first, formation of a mineral layer of calcium phosphate and second, stimulation of osteogenesis.1


synthes 1

Activioss™ dissolution brings about ionic exchanges with biological fluids able to form a mineral layer of calcium phosphate, which allows binding between the biomaterial granules and the bone. This binding will prevent any micro-movement of the granules, which would prevent osteointegration.1 2


synthes 2

Characterization of the mineral layer formed on Activioss™ granules after 45 days, Scanning Electron Microscope.



The release of an optimum level of silicium will genetically stimulate the recruitment and proliferation of the stem cells and the differentiation and proliferation of the osteoblasts: these are the main agents of osteogenesis. This is osteostimulation.

The intrinsic properties of Activioss™ help to promote the natural process of bone regeneration, thanks to the release of mineral ions. This innovative technology offers the safest and most effective solution for dental surgeons and for their patients.



1 - Hench, L.L. The story of Bioglass. J Matter Sci: Matter Med. Springer Science, 2006, Vol. 17, p. 967-978.
2 - Jones, J.R. Review of bioactive glass: from Hench to hybrids. Acta Biomaterialia. Elsevier, 2013, Vol. 9, pp.4457-4486.

Osteostimulative


Accelerates full natural bone remodelling

Activioss™ accelerates natural bone regeneration 2 time.


The high level of silicium in the composition of Activioss™ bone graft substitute and its dissolution brings about the bioactivity process. Activioss™ genetically stimulates the recruitment, differentiation and proliferation of the stem cells in osteoblasts for complete and natural bone remodelling. (Mechanism of action).3 4 5 6

The new bone and capillaries form rapidly between the granules, restoring the natural biological and mechanical properties of the bone. Bone growth is approximately twice as fast as the bone growth observed with the use of others synthetic bone substitutes.7 The natural bone remodelling guarantees successful clinical results.



Osteostimulateur
Studies showed the percentage of bone formation. The bioactive glass 45S5 allows bone restoration in two weeks instead of the six weeks required by other inert ceramics to achieve the same result.

Osteostimulateur 2
Histological section at 26 weeks of the filling of a sinus floor in a human. The edges of the osteoid are extensive and thick in the newly formed tissue, and there are large numbers of resorption cavities. This means that the remodelling is intense with extensive formation and resorption.

3 - Jell, G. and al. Gene activation by bioactive glasses. J Mater Sci: Mater Med. Springer Science, 2006, Vol. 17, pp.997-1002.
4 - Xynos, I.D. and al. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochemical and Biophysical Research - Communications. 2000, Vol. 276, 2, pp. 461-5.
5 - Hench, L.L. Genetic design of biactive glass. Journal of the European Ceramic Society. Elsevier, 2009, Vol. 29, pp. 1257-1265.
6 - Tsigkou, O. and al. Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass conditioned medium in the absence of osteogenic supplements. Biomaterials. Elsevier, 2009, Vol. 30, pp.3542-50.
7 - Oonishi, H. and al. Quantitative comparison of bone growth behavior in granules of Bioglass, A-W glass ceramic and hydroxyapatite. J Biomed Mater Res. John Wiley & Sons, Inc., 2000, Vol. 51.

Hydrophilic


Optimal handling & easy to use

Activioss™ has a good degree of hydrophilic property.


Activioss™ has a high affinity for biologic fluids which improves its handling. When it is mixed with patients' blood or with normal saline solution, it forms a cohesive mass, making it easy to handle and implant in the mouth of the patient.


Hydrophile

From the first instants after humidification, the blood enters the granular clusters. Activioss™ can be mixed with a low volume of blood. This strong hydrophilic property is characterized by hydrogen bonds between the blood and the bone graft substitute.


Volume Preservation


Aesthetic guaranteed

Optimal bioabsorption for a complete bone remodelling.


The aesthetic requirements of your patients can be met with the restoration and preservation of bone volume. Bone volume preservation is the result of bone graft substitute bioabsorption and bone remodelling that takes place. Activioss™ degradation is ensured because it dissolves after implantation which will initiate bone remodelling.2


Maintien Volume 3

Restoration and preservation of bone volume are guaranteed by bone regeneration with natural biological and mechanical properties, meaning success for your clinical cases.

Maintien Volume 2
The dissolution of Activioss™ stimulates the natural process of bone regeneration. It has been demonstrated on the one hand that the use of Bioactive Glass 45S5 is at least as effective as autologous bone, and on the other hand that the use of Bioactive Glass 45S5 in combination with autologous bone leads to bone growth that is twice as fast as with autologous bone alone.

2 - Jones, J.R. Review of bioactive glass: from Hench to hybrids. Acta Biomaterialia. Elsevier, 2013, Vol. 9, pp.4457-4486.

Synthetic


Reliable, predictable and reproducible results

100% synthetic, 100% sure, 45% bioactive elements.


Activioss™ belongs to the family of bioactive glasses, a synthetic and bioactive bone substitute. It is composed of mineral elements such as silicium, calcium, sodium and phosphorus. All of the mineral ions that make up Activioss™ are naturally present in the human body and are known to play physiologically crucial roles in the process of bone formation and mineralisation.8 This composition overcomes the risk of transmission of pathogens and provides optimum safety for patients and surgeons.


Synthese 2

The 45% of silicium in the compound of Activioss™ ensures bioactivity in the process of natural bone regeneration.



Synthese 3

8 - Hoppe, A., Nusret, S.G. and Boccaccini, A.R. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. Elsevier, 2011, Vol. 32, pp. 2757-2774.

Antibacterial effect


Optimal safety

Activioss™ has the ability to inhibit bacterial proliferation.


The ions released after implantation of Activioss™ contribute to the increase in pH of the medium and the increase in osmotic pressure. These two effects are responsible for antibacterial activity.9 10This local antibacterial effect is both bacteriostatic and bactericidal, and has been demonstrated on supragingival and subgingival bacteria with an efficacy that depends on the species of bacterium.


Synthese 2
Synthese 3 The Activioss™ effect on 29 pathogens.
3 - Good growth,
2 - Moderate growth,
1 - Poor growth,
0 - No growth.

Activioss™ with ion release plays a part in the physiological processes which lead to successful surgery.



9 - Allan, I., Newman, H. and Wilson, M. Antibacterial activity of particulate Bioglass against supra- and subgingival bacteria. Biomaterials. Elsevier, 2001, Vol.22, pp. 1683-1687.
10 - Manukka, A. and al. Bactericidal effects of bioactive glasses on clinically important aerobic bacteria. J Mater Sci: Mater Med. Springer Science, 2008, Vol. 19.

The Activioss™ synthetic and bioactive bone substitute is indicated in the temporary filling of a defect caused by trauma, disease or surgery, with a view to bone regeneration:
- Bone crest augmentation (surgery before and during the implant),
- Sinus floor elevation (sinus Lift or Summer's technique),
- Infrabony periodontal defects,
- Filling of bone lesions of type dental cysts or granulomas,
- Volume preservation in the extraction sites.

Indications

Activioss™ has to be mixed normal saline solution, autologous bone, patient blood or PRF (Platelet-Rich Fibrin). In order to enhance the host site vascularization, heighten the host cortical bone walls. When placing the graft material, pack it with a compress moistened by normal saline solution. Excess filling is recommended.

Activioss
DOCUMENTATION
AVAILABLE

Ressources



NORAKER participates in international conferences and others national and regional seminars. Do not hesitate to contact us to meet us at these events.

Participation as an exhibitor:



Sept 29th
Oct 1st 2016
European Congress of EAO – Paris (FR). Noraker will be present on the booth B22. More information on www.eao-congress.com

Nov 10-12
2016
EXPODENTARIA – Porto (PT). More information on www.omd.pt/congresso/2015/expodentaria

Nov 14-17th
2016
MEDICA – Düsseldorf (GE). Noraker will be present on the Hall 4 booth H16E. More information on www.medica-tradefair.com

Nov 22-26th
2016
National congress of Dental ADF - Paris (FR). Noraker will be present, more information on www.adf.asso.fr

Jan 30th
Feb 2nd2017
Arab Health – Dubai (AE). Noraker will be present, more information on www.arabhealthonline.com

March 21
25th2017
International Dental Show IDS, Cologne (GE). NORAKER will be present on the IDS congress, Hall 11.3 stand B-049. More information on www.english.ids-cologne.de


Bioactive glass granules for regeneration of human periodontal defects. Rosenberg ES, Fox GK, Cohen C. 5, 2000, J Esthet Dent, Vol. 12, pp. 248-57.

A Clinical and Radiographic Evaluation of Periodontal Regenerative Potential of PerioGlas®: A Synthetic, Resorbable Material in Treating Periodontal Infrabony Defects. Chacko NL, Abraham S, Rao HN, Sridhar N, Moon N, Barde DH. 3, 2014, J Int Oral Health, Vol. 6, pp. 20-6.

Clinical evaluation of intrabony defects in localized aggressive periodontitis patients with and without bioglass- an in-vivo study. Satyanarayana KV, Anuradha BR, Srikanth G, Chandra PM, Anupama T, Durga PM. 37, 2012, Kathmandu Univ Med J, Vol. 10, pp. 11-5.

Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects. Sumer M, Keles GC, Cetinkaya BO, Balli U, Pamuk F, Uckan S. 1, 2013, Eur J Dent, Vol. 7, pp. 6-14.

Effects of bioactive glass, hydroxyapatite and bioactive glass - Hydroxyapatite composite graft particles in the treatment of infrabony defects. Mistry S, Kundu D, Datta S, Basu D. 2, J Indian Soc Periodontol, Vol. 16, pp. 241-6.

Le verre bioactif 45S5 : Une alternative aux greffes naturelles d’origine bovine dans le R.O.G. Carrotte D, 2015, Le Fil Dentaire N°104 p24

Immediate Non-functional Loading of Single Tooth Uniti™ Implants into Avulsed Tooth Sockets Following Ridge Augmentation in the Anterior Maxilla: A Case Series. Vijayanathan R, Anil Kumar S, Datana S, Kosala M. 2013, J Maxillofac Oral Surg, pp. 203-9.

Three-dimensional evaluation of bone changes following ridge preservation procedures. Clozza E, Biasotto M, Cavalli F, Moimas L, Di Lenarda R. 4, 2012, Int J Oral Maxillofac Implants, Vol. 27, pp. 770-5.

Bioactive glass for alveolar ridge augmentation. Margonar R, Queiroz TP, Luvizuto ER, Marcantonio É, Lia RC, Holzhausen M, Marcantonio-Júnior. 3, 2012, J Craniofac Surg, Vol. 23, pp. e220-2.

Assessment of the value of anorganic bone additives in sinus floor augmentation: a review of clinical reports. Merkx MA, Maltha JC, Stoelinga PJ. 1, 2003, Int J Oral Maxillofac Surg, Vol. 32.

News & Contact Us



Contact Us


You are a surgeon, a distributor, everyone is entitled to his personal information, do not hesitate to contact us:

*
*
*
*
*
*

News


September 29th-October 1st 2016: European Congress of EAO – Paris (FR). Noraker will be present on the booth B22. More information on www.eao-congress.com
November 10-12 2016: EXPODENTARIA – Porto (PT). More information on www.omd.pt/congresso/2015/expodentaria
November 14-17th 2016: MEDICA – Düsseldorf (GE). Noraker will be present on the Hall 4 booth H16E. More information on www.medica-tradefair.com
November 22-26th 2016: National congress of Dental ADF - Paris (FR). Noraker will be present, more information on www.adf.asso.fr
January 30th-February 2nd 2017: Arab Health – Dubai (AE). Noraker will be present, more information on www.arabhealthonline.com
March 21-25th 2017: International Dental Show IDS, Cologne (GE). NORAKER will be present on the IDS congress, Hall 11.3 stand B-049. More information on www.english.ids-cologne.de



As an innovative company, NORAKER is not represented in all regions of the world. If you wear an interest in our products, please do not hesitate to contact us.

Legal Notices


Editorial Management
Activioss
Centre Scientifique et Technologique Albert Einstein
13 avenue Albert Einstein
69100 VILLEURBANNE
Tél : +33 (0) 4 78 93 30 92
Fax : +33 (0) 4 72 35 94 37
E-mail : contact@noraker.com


Design & Web-design
SYNTHES'3D
1 Rue Mahatma GANDHI
Le Décisium - Bât C1
13 090 Aix-en-Provence - France
E-mail : contact@synthes3d.com


Hosting
OVH
RCS Roubaix – Tourcoing 424 761 419 00045
Code APE 6202A
N° TVA : FR 22 424 761 419
Siège social : 2 rue Kellermann - 59100 Roubaix - France

COPYRIGHTS
The general information on the Website www.noraker.com is intended for health professionals and the general public. Information of a promotional nature is intended solely for health care professionals.

INTELLECTUAL PROPERTY RIGHTS
The presentation and content of this Website together make up a work protected under current intellectual property laws of which Noraker is the rights-holder. The use or reproduction, even partial, of the texts, photos or graphics it contains is prohibited without the prior written agreement of Noraker and would be liable to amount to infringement. Similarly, any reproduction, representation, adaptation, translation and/or modification, partial or whole, or transfer towards another site is prohibited.
In accordance with article L122-4 of the French Intellectual Property Code, "Any complete or partial representation or reproduction made without the consent of the author or of his successors in title or assigns shall be unlawful. The same shall apply to translation, adaptation or transformation, arrangement or reproduction by any technique or process whatsoever".
Noraker recalls that the elements shown on this Website may be freely consulted for private, information or educational purposes. All other forms of exploitation thereof would amount to acts of infringement of their author's rights, as provided and punished by articles L335-4 et seq of the French Intellectual Property Code.
In accordance with article L342-1 of the French Intellectual Property Code, Noraker forbids the extraction by permanent or temporary transfer onto all kinds of media by any means and in any form whatsoever of the whole or a substantial part of the content of this Website, except if these operations are carried out for purely private, information or educational purposes. It also forbids the re-use, by making available to the public, of the whole or a part only of the site's content or of any of the elements making up the same, regardless of the form.

PHOTO CREDITS
All rights reserved for the photographs illustrating this site.

NO WARRANTY
The Website, information and functionalities proposed correspond to current legal rules. However, use thereof is at your own liability. Noraker and its affiliates and partners give no warranty as to the correctness, commercial value, quality or absence of infringement of any information published on the Website or available thanks to the site.
In addition, Noraker, its affiliates and partners can give no warranty that the server which makes the Website accessible is protected against any virus liable to cause damage to, infect or destroy your computer set-up or any other installation when accessing this Website, downloading a document or calling upon any other functionality on the site.
In accordance with the law, Noraker, its affiliates and partners shall not in any manner be held liable for direct or indirect damage, whether accidental or not, ensuing from the proper or improper use of the Website. Similarly, Noraker, its affiliates and partners shall not in any manner be held liable for direct or indirect damage caused by errors or omissions found on this Website in the information disclosed among the functionalities offered.
Noraker, its affiliates and partners reserve the right to alter, add or remove the terms and conditions of use at any time without notice. These changes shall apply as soon as they are published on the site. Consulting the site once these changes have been made automatically implies acceptance thereof. Noraker also reserves the right to alter, add or remove all or part of the content or functionalities of the site at any time without prior warning and without the liability of Noraker, its affiliates or partners being incurred or relied on by the visitor to the site.

PERSONAL DATA
Any information that might be collected from you by your use of the Website is intended strictly for Noraker only with the aim of compiling a list of people interested in its activities and, more particularly, by those on this site, and will not be passed on to third parties.
No personal information is collected without your knowledge.
No personal information is transferred to third parties, free of charge or for consideration. No personal information is used for purposes other than those stated here.
Under article 34 of the French Data Protection Act, you have the right to access, modify and delete personal data relating to you.