Activioss Slide 1 Activioss Slide 2 Activioss Slide 4 Activioss Slide 6


Functional and aesthetic restoration are daily challenges for dental surgeons. The choice of treatment and implants and high performance bone substitutes are the answer to the specificity of clinical cases.

Activioss™ is indicated in regenerative medicine. It combines natural biological action and optimum safety for reliable and reproducible results.

Activioss™ is a synthetic, bioactive bone substitute which comes in the form of granules.

Based on innovative technology, Activioss™ is a Bioactive Glass 45S5 ceramic composed of silicium, sodium, phosphorus and calcium oxide. All of these elements are naturally present in the human body and are crucial agents in the osteogenesis process. This bioactivity, marks a new stage in bone regeneration products.

The mineral ion formula of Activioss™ increases its biocompatibility and removes the risk of transmitting pathogens. The bone regeneration product Activioss™ comes from a technology developed in France with local partners to ensure highest quality.

Activioss™ offers dentists and patients optimum safety during implantation for natural, effective bone restoration for all indication encountered in daily dental practice.

Activioss™ Granule, medical device class III, manufactured by Noraker, CE Mark n° (0459). Activioss™ Granule is a biomaterial of bone substitution, indicated in bone defect filling. Read the instructions supplied with the product for complete information.
Packaging Activioss




Volume Preservation


Activioss 1
Activioss 2 Activioss 3


Stimules osteogenesis

Activioss™ has a higher degree of bioactivity.

Natural bone remodelling of the patient is the major factor in dental implant osteointegration. Bioactivity of Activioss™ ensures natural bone remodelling in two crucial stages: first, formation of a mineral layer of calcium phosphate and second, stimulation of osteogenesis.1

synthes 1

Activioss™ dissolution brings about ionic exchanges with biological fluids able to form a mineral layer of calcium phosphate, which allows binding between the biomaterial granules and the bone. This binding will prevent any micro-movement of the granules, which would prevent osteointegration.1 2

synthes 2

Characterization of the mineral layer formed on Activioss™ granules after 45 days, Scanning Electron Microscope.

The release of an optimum level of silicium will genetically stimulate the recruitment and proliferation of the stem cells and the differentiation and proliferation of the osteoblasts: these are the main agents of osteogenesis. This is osteostimulation.

The intrinsic properties of Activioss™ help to promote the natural process of bone regeneration, thanks to the release of mineral ions. This innovative technology offers the safest and most effective solution for dental surgeons and for their patients.

1 - Hench, L.L. The story of Bioglass. J Matter Sci: Matter Med. Springer Science, 2006, Vol. 17, p. 967-978.
2 - Jones, J.R. Review of bioactive glass: from Hench to hybrids. Acta Biomaterialia. Elsevier, 2013, Vol. 9, pp.4457-4486.


Accelerates full natural bone remodelling

Activioss™ accelerates natural bone regeneration 2 time.

The high level of silicium in the composition of Activioss™ bone graft substitute and its dissolution brings about the bioactivity process. Activioss™ genetically stimulates the recruitment, differentiation and proliferation of the stem cells in osteoblasts for complete and natural bone remodelling. (Mechanism of action).3 4 5 6

The new bone and capillaries form rapidly between the granules, restoring the natural biological and mechanical properties of the bone. Bone growth is approximately twice as fast as the bone growth observed with the use of others synthetic bone substitutes.7 The natural bone remodelling guarantees successful clinical results.

Studies showed the percentage of bone formation. The bioactive glass 45S5 allows bone restoration in two weeks instead of the six weeks required by other inert ceramics to achieve the same result.

Osteostimulateur 2
Histological section at 26 weeks of the filling of a sinus floor in a human. The edges of the osteoid are extensive and thick in the newly formed tissue, and there are large numbers of resorption cavities. This means that the remodelling is intense with extensive formation and resorption.

3 - Jell, G. and al. Gene activation by bioactive glasses. J Mater Sci: Mater Med. Springer Science, 2006, Vol. 17, pp.997-1002.
4 - Xynos, I.D. and al. Ionic products of bioactive glass dissolution increase proliferation of human osteoblasts and induce insulin-like growth factor II mRNA expression and protein synthesis. Biochemical and Biophysical Research - Communications. 2000, Vol. 276, 2, pp. 461-5.
5 - Hench, L.L. Genetic design of biactive glass. Journal of the European Ceramic Society. Elsevier, 2009, Vol. 29, pp. 1257-1265.
6 - Tsigkou, O. and al. Differentiation of fetal osteoblasts and formation of mineralized bone nodules by 45S5 Bioglass conditioned medium in the absence of osteogenic supplements. Biomaterials. Elsevier, 2009, Vol. 30, pp.3542-50.
7 - Oonishi, H. and al. Quantitative comparison of bone growth behavior in granules of Bioglass, A-W glass ceramic and hydroxyapatite. J Biomed Mater Res. John Wiley & Sons, Inc., 2000, Vol. 51.


Optimal handling & easy to use

Activioss™ has a good degree of hydrophilic property.

Activioss™ has a high affinity for biologic fluids which improves its handling. When it is mixed with patients' blood or with normal saline solution, it forms a cohesive mass, making it easy to handle and implant in the mouth of the patient.


From the first instants after humidification, the blood enters the granular clusters. Activioss™ can be mixed with a low volume of blood. This strong hydrophilic property is characterized by hydrogen bonds between the blood and the bone graft substitute.

Volume Preservation

Aesthetic guaranteed

Optimal bioabsorption for a complete bone remodelling.

The aesthetic requirements of your patients can be met with the restoration and preservation of bone volume. Bone volume preservation is the result of bone graft substitute bioabsorption and bone remodelling that takes place. Activioss™ degradation is ensured because it dissolves after implantation which will initiate bone remodelling.2

Maintien Volume 3

Restoration and preservation of bone volume are guaranteed by bone regeneration with natural biological and mechanical properties, meaning success for your clinical cases.

Maintien Volume 2
The dissolution of Activioss™ stimulates the natural process of bone regeneration. It has been demonstrated on the one hand that the use of Bioactive Glass 45S5 is at least as effective as autologous bone, and on the other hand that the use of Bioactive Glass 45S5 in combination with autologous bone leads to bone growth that is twice as fast as with autologous bone alone.

2 - Jones, J.R. Review of bioactive glass: from Hench to hybrids. Acta Biomaterialia. Elsevier, 2013, Vol. 9, pp.4457-4486.


Reliable, predictable and reproducible results

100% synthetic, 100% sure, 45% bioactive elements.

Activioss™ belongs to the family of bioactive glasses, a synthetic and bioactive bone substitute. It is composed of mineral elements such as silicium, calcium, sodium and phosphorus. All of the mineral ions that make up Activioss™ are naturally present in the human body and are known to play physiologically crucial roles in the process of bone formation and mineralisation.8 This composition overcomes the risk of transmission of pathogens and provides optimum safety for patients and surgeons.

Synthese 2

The 45% of silicium in the compound of Activioss™ ensures bioactivity in the process of natural bone regeneration.

Synthese 3

8 - Hoppe, A., Nusret, S.G. and Boccaccini, A.R. A review of the biological response to ionic dissolution products from bioactive glasses and glass-ceramics. Biomaterials. Elsevier, 2011, Vol. 32, pp. 2757-2774.

The Activioss™ synthetic and bioactive bone substitute is indicated in the temporary filling of a defect caused by trauma, disease or surgery, with a view to bone regeneration:
- Bone crest augmentation (surgery before and during the implant),
- Sinus floor elevation (sinus Lift or Summer's technique),
- Infrabony periodontal defects,
- Filling of bone lesions of type dental cysts or granulomas,
- Volume preservation in the extraction sites.


Activioss™ has to be mixed normal saline solution, autologous bone, patient blood or PRF (Platelet-Rich Fibrin). In order to enhance the host site vascularization, heighten the host cortical bone walls. When placing the graft material, pack it with a compress moistened by normal saline solution. Excess filling is recommended.



NORAKER participates in international conferences and others national and regional seminars. Do not hesitate to contact us to meet us at these events.

Participation as an exhibitor:

Sept 29th
Oct 1st 2016
European Congress of EAO – Paris (FR). Noraker will be present on the booth B22. More information on

Nov 10-12
EXPODENTARIA – Porto (PT). More information on

Nov 14-17th
MEDICA – Düsseldorf (GE). Noraker will be present on the Hall 4 booth H16E. More information on

Nov 22-26th
National congress of Dental ADF - Paris (FR). Noraker will be present, more information on

Jan 30th
Feb 2nd2017
Arab Health – Dubai (AE). Noraker will be present, more information on

March 21
International Dental Show IDS, Cologne (GE). NORAKER will be present on the IDS congress, Hall 11.3 stand B-049. More information on

Bioactive glass granules for regeneration of human periodontal defects. Rosenberg ES, Fox GK, Cohen C. 5, 2000, J Esthet Dent, Vol. 12, pp. 248-57.

A Clinical and Radiographic Evaluation of Periodontal Regenerative Potential of PerioGlas®: A Synthetic, Resorbable Material in Treating Periodontal Infrabony Defects. Chacko NL, Abraham S, Rao HN, Sridhar N, Moon N, Barde DH. 3, 2014, J Int Oral Health, Vol. 6, pp. 20-6.

Clinical evaluation of intrabony defects in localized aggressive periodontitis patients with and without bioglass- an in-vivo study. Satyanarayana KV, Anuradha BR, Srikanth G, Chandra PM, Anupama T, Durga PM. 37, 2012, Kathmandu Univ Med J, Vol. 10, pp. 11-5.

Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects. Sumer M, Keles GC, Cetinkaya BO, Balli U, Pamuk F, Uckan S. 1, 2013, Eur J Dent, Vol. 7, pp. 6-14.

Effects of bioactive glass, hydroxyapatite and bioactive glass - Hydroxyapatite composite graft particles in the treatment of infrabony defects. Mistry S, Kundu D, Datta S, Basu D. 2, J Indian Soc Periodontol, Vol. 16, pp. 241-6.

Le verre bioactif 45S5 : Une alternative aux greffes naturelles d’origine bovine dans le R.O.G. Carrotte D, 2015, Le Fil Dentaire N°104 p24

Immediate Non-functional Loading of Single Tooth Uniti™ Implants into Avulsed Tooth Sockets Following Ridge Augmentation in the Anterior Maxilla: A Case Series. Vijayanathan R, Anil Kumar S, Datana S, Kosala M. 2013, J Maxillofac Oral Surg, pp. 203-9.

Three-dimensional evaluation of bone changes following ridge preservation procedures. Clozza E, Biasotto M, Cavalli F, Moimas L, Di Lenarda R. 4, 2012, Int J Oral Maxillofac Implants, Vol. 27, pp. 770-5.

Bioactive glass for alveolar ridge augmentation. Margonar R, Queiroz TP, Luvizuto ER, Marcantonio É, Lia RC, Holzhausen M, Marcantonio-Júnior. 3, 2012, J Craniofac Surg, Vol. 23, pp. e220-2.

Assessment of the value of anorganic bone additives in sinus floor augmentation: a review of clinical reports. Merkx MA, Maltha JC, Stoelinga PJ. 1, 2003, Int J Oral Maxillofac Surg, Vol. 32.

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You are a surgeon, a distributor, everyone is entitled to his personal information, do not hesitate to contact us:



September 29th-October 1st 2016: European Congress of EAO – Paris (FR). Noraker will be present on the booth B22. More information on
November 10-12 2016: EXPODENTARIA – Porto (PT). More information on
November 14-17th 2016: MEDICA – Düsseldorf (GE). Noraker will be present on the Hall 4 booth H16E. More information on
November 22-26th 2016: National congress of Dental ADF - Paris (FR). Noraker will be present, more information on
January 30th-February 2nd 2017: Arab Health – Dubai (AE). Noraker will be present, more information on
March 21-25th 2017: International Dental Show IDS, Cologne (GE). NORAKER will be present on the IDS congress, Hall 11.3 stand B-049. More information on

As an innovative company, NORAKER is not represented in all regions of the world. If you wear an interest in our products, please do not hesitate to contact us.

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