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Activioss™ is a resorbable bilayer synthetic membrane, with a biomimetic structure to promote full bone regeneration. Its synthetic property induces reliable characteristics, in terms of fabrication, in order to ensure predictable and reproducible results.1

Activioss™ Membrane is made of synthetic polymer: the choice of this material ensures an excellent biocompatibility and an optimal resorption, allowing hard and soft tissues regeneration.1 2 3

Activioss™ Membrane is indicated in Guided Bone Regeneration and Guided Tissue Regeneration. The isolation of the bone defect, combined with the bone filling Activioss™ Granule offers a 100% synthetic solution.


Resistant and supple, setting up Activioss™ Membrane is easy, and allows the blood clot fixation, favoring tissue healing.
The Jet-Spraying technology is a French patented technology, allowing manufacturing a bilayer membrane, with a rough biomimetic structure. This nano-fibrillar layer has a 10 µm porosity, to allow blood vessels and bone cells development between the fibers.1

The thick and smooth layer has been developed to ensure a full barrier effect during the 4 first critical weeks for gingival tissues healing. Moreover, the Jet-Spraying technology and the polymer selection allowed developing a membrane with a good physiological tolerance, to allow a 6 months degradation, with a gradual and controlled process.1 2 3



1. Hoornaert A., Layrolle P., Sohier J. Membrane de régénération osseuse et procédé de formation d’une membrane de régénération osseuse. EP2404627, 2010.
2. Hoornaert A., Arros C., Heymann M-A, Layrolle P. Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration. Biomedical Materials, 2016, Revised article submitted on April 29, 2016
3. Kulkarni RK, Pani KC, Neuman C,Leonard F. Polylactic acid for surgical implants. Archives of Surgery 1966;93:839-843.




Activioss™ Membrane, medical device class III, manufactured by Biomedical Tissues, CE Mark n°(0459). Activioss™ Membrane is indicated for periodontal and implant surgery. Read the instructions supplied with the product for complete information.
Packaging Activioss

Jet-Spraying Technology

Handling Experience

Full barrier effect

Slow and controlled resorption

DOCUMENTATION
DISPONIBLE

Jet-Spraying Technology


Activioss™ Membrane is produced by a patented Jet-Spraying technology, which gives it a bilayer structure, with a thick and smooth layer to prevent connective tissue invagination and to ensure mechanical resistance, and a rough biomimetic layer to support osteoblastic cells colonization and to promote full bone regeneration.1


Technologie brevetée 1

1. Hoornaert A., Layrolle P., Sohier J. Membrane de régénération osseuse et procédé de formation d’une membrane de régénération osseuse. EP2404627, 2010.


Handling Experience:


Blood clot fixation

Mechanical properties of Activioss™ membrane make it flexible and resistant. It can be cut, repositioned, sutured, without sticking to the instrumentation..2 4 Membrane’s resistance and the intact full barrier effect during 4 weeks are essential factors to maintain the blood clot and the filled volume, and to optimize bone regeneration.2 4



expérience de manipulation Activioss™ Membrane is both supple and flexible and adaptable to many bone defects.


2. Hoornaert A., Arros C., Heymann M-A, Layrolle P. Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration. Biomedical Materials, 2016, Revised article submitted on April 29, 2016
4. Retzepi M, Donos N. Guided Bone Regeneration: biological principle and therapeutic applications. Clin. Oral Impl. Res. 21 (2010) 567–76.

Full barrier effect for 4 weeks:


Biomimetic bilayer structure

During the first 4 weeks, the membrane’s thick layer preserves its integrity to ensure the barrier effect during the critical step of gingival tissue healing. It avoids soft tissues invagination in bone defect, while stabilizing the blood clot.1 2 4

The rough biomimetic layer is composed of entangled fibers with a 10 µm porosity, facilitating the passage of blood vessels and bone cells.1 2

The association with a bioactive bone substitute and the presence of bone remodeling actors favor bone tissue regeneration.


histologie   histologie
Subcutaneous histological study, at 4 weeks: The thick layer (in white) remains intact, no adipose tissue infiltration was observed. No signs of inflammation or infection were observed. Cell colonization is observed on the rough layer after 4 weeks.*

  Subcutaneous histological study, at 8 weeks: The thick layer (in white) of Activioss™ membrane is still apparent, but with multiples lysis.*
couche   couche
in-vitro   in-vitro
In-vivo study at 4 weeks: The bilayer structure of Activioss™ membrane is still present, with a good healing. A centripetal bone healing can be observed on the radiography at 4 weeks.*   In-vivo study at 8 weeks: Activioss™ membrane confirms its capacity to isolate the defect and to lead bone regeneration (in green). A bone bond is present on the radiography, in a critical size defect.*


1. Hoornaert A., Layrolle P., Sohier J. Membrane de régénération osseuse et procédé de formation d’une membrane de régénération osseuse. EP2404627, 2010.
2. Hoornaert A., Arros C., Heymann M-A, Layrolle P. Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration. Biomedical Materials, 2016, Revised article submitted on April 29, 2016
4. Retzepi M, Donos N. Guided Bone Regeneration: biological principle and therapeutic applications. Clin. Oral Impl. Res. 21 (2010) 567–76.
* Les résultats de cette étude ne prévalent pas des résultats chez l'homme.

Slow and controlled resorption in 6 months


Bioresorbable

From the first weeks, the rough layer of Activioss™ Membrane will degrade by hydrolysis of the polymer chains. Gradually, the fibers break up, leaving blood vessels and bone cells to induce bone regeneration.2

After 8 weeks, the thick and smooth layer lyses in multiple points, to be finally fully absorbed by the organism at 4 & 8 weeks.2

The Activioss™ Membrane resorption is full after 6 months (Graphic 1). This slow and controlled resorption, combined with a bioactive bone substitute, favors a quality bone regeneration.2


Biorésorbable Graph 1: Barrier effect and resorption. Activioss™ Membrane is stable during the first 4 weeks, and gradually degraded in a 6 months period.*

2. Hoornaert A., Arros C., Heymann M-A, Layrolle P. Biocompatibility, resorption and biofunctionality of a new synthetic biodegradable membrane for guided bone regeneration. Biomedical Materials, 2016, Revised article submitted on April 29, 2016
* Les résultats de cette étude ne prévalent pas des résultats chez l'homme.



The resorbable bilayer synthetic Activioss™ Membrane is indicated in Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR), in periodontal and implant surgery:

- Sinus floor elevation
- Extraction socket
- Periodontal treatments
- Bone augmentation
- Bony dehiscence and apical fenestration


The Activioss™ range is composed of 3 product references:



Tableau de références

gencive
DOCUMENTATION
AVAILABLE

Ressources



NORAKER participates in international conferences and others national and regional seminars. Do not hesitate to contact us to meet us at these events.

Participation as an exhibitor:



Sept 29th
Oct 1st 2016
European Congress of EAO – Paris (FR). Noraker will be present on the booth B22. More information on www.eao-congress.com

Nov 10-12
2016
EXPODENTARIA – Porto (PT). More information on www.omd.pt/congresso/2015/expodentaria

Nov 14-17th
2016
MEDICA – Düsseldorf (GE). Noraker will be present on the Hall 4 booth H16E. More information on www.medica-tradefair.com

Nov 22-26th
2016
National congress of Dental ADF - Paris (FR). Noraker will be present, more information on www.adf.asso.fr

Jan 30th
Feb 2nd2017
Arab Health – Dubai (AE). Noraker will be present, more information on www.arabhealthonline.com

March 21
25th2017
International Dental Show IDS, Cologne (GE). NORAKER will be present on the IDS congress, Hall 11.3 stand B-049. More information on www.english.ids-cologne.de


Bioactive glass granules for regeneration of human periodontal defects. Rosenberg ES, Fox GK, Cohen C. 5, 2000, J Esthet Dent, Vol. 12, pp. 248-57.

A Clinical and Radiographic Evaluation of Periodontal Regenerative Potential of PerioGlas®: A Synthetic, Resorbable Material in Treating Periodontal Infrabony Defects. Chacko NL, Abraham S, Rao HN, Sridhar N, Moon N, Barde DH. 3, 2014, J Int Oral Health, Vol. 6, pp. 20-6.

Clinical evaluation of intrabony defects in localized aggressive periodontitis patients with and without bioglass- an in-vivo study. Satyanarayana KV, Anuradha BR, Srikanth G, Chandra PM, Anupama T, Durga PM. 37, 2012, Kathmandu Univ Med J, Vol. 10, pp. 11-5.

Autogenous cortical bone and bioactive glass grafting for treatment of intraosseous periodontal defects. Sumer M, Keles GC, Cetinkaya BO, Balli U, Pamuk F, Uckan S. 1, 2013, Eur J Dent, Vol. 7, pp. 6-14.

Effects of bioactive glass, hydroxyapatite and bioactive glass - Hydroxyapatite composite graft particles in the treatment of infrabony defects. Mistry S, Kundu D, Datta S, Basu D. 2, J Indian Soc Periodontol, Vol. 16, pp. 241-6.

Le verre bioactif 45S5 : Une alternative aux greffes naturelles d’origine bovine dans le R.O.G. Carrotte D, 2015, Le Fil Dentaire N°104 p24

Immediate Non-functional Loading of Single Tooth Uniti™ Implants into Avulsed Tooth Sockets Following Ridge Augmentation in the Anterior Maxilla: A Case Series. Vijayanathan R, Anil Kumar S, Datana S, Kosala M. 2013, J Maxillofac Oral Surg, pp. 203-9.

Three-dimensional evaluation of bone changes following ridge preservation procedures. Clozza E, Biasotto M, Cavalli F, Moimas L, Di Lenarda R. 4, 2012, Int J Oral Maxillofac Implants, Vol. 27, pp. 770-5.

Bioactive glass for alveolar ridge augmentation. Margonar R, Queiroz TP, Luvizuto ER, Marcantonio É, Lia RC, Holzhausen M, Marcantonio-Júnior. 3, 2012, J Craniofac Surg, Vol. 23, pp. e220-2.

Assessment of the value of anorganic bone additives in sinus floor augmentation: a review of clinical reports. Merkx MA, Maltha JC, Stoelinga PJ. 1, 2003, Int J Oral Maxillofac Surg, Vol. 32.

Histological evaluation of healing after transalveolar maxillary sinus augmentation with bioglass and autogenous bone. Stavropoulos A, Sima C, Sima A, Nyengaard J, Karring T, Sculean A. 1, 2012, Clin Oral Implants Res, Vol. 23, pp. 125-31.
Clinical and histologic comparison of two different composite grafts for sinus augmentation: a pilot clinical trial. Galindo-Moreno P, Avila G, Fernández-Barbero JE, Mesa F, O'Valle-Ravassa F, Wang HL. 8, 2008, Clin Oral Implants Res, Vol. 19, pp. 755-9.
Maxillary sinus augmentation with different biomaterials: a comparative histologic and histomorphometric study in man. Scarano A, Degidi M, Iezzi G, Pecora G, Piattelli M, Orsini G, Caputi S, Perrotti V, Mangano C, Piattelli A. 2, 2006, Implant Dent, Vol. 15, pp. 197-207.
Management of radicular cysts using platelet-rich fibrin and bioactive glass: a report of two cases. Zhao JH, Tsai CH, Chang YC. 7, 2014, J Formos Med Assoc, Vol. 113, pp. 470-6.
Histological comparison of healing extraction sockets implanted with bioactive glass or demineralized freeze-dried bone allograft: a pilot study. Froum S, Cho SC, Rosenberg E, Rohrer M, Tarnow D. 1, 2002, J Periodontol, Vol. 73, pp. 94-102.

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News


September 29th-October 1st 2016: European Congress of EAO – Paris (FR). Noraker will be present on the booth B22. More information on www.eao-congress.com
November 10-12 2016: EXPODENTARIA – Porto (PT). More information on www.omd.pt/congresso/2015/expodentaria
November 14-17th 2016: MEDICA – Düsseldorf (GE). Noraker will be present on the Hall 4 booth H16E. More information on www.medica-tradefair.com
November 22-26th 2016: National congress of Dental ADF - Paris (FR). Noraker will be present, more information on www.adf.asso.fr
January 30th-February 2nd 2017: Arab Health – Dubai (AE). Noraker will be present, more information on www.arabhealthonline.com
March 21-25th 2017: International Dental Show IDS, Cologne (GE). NORAKER will be present on the IDS congress, Hall 11.3 stand B-049. More information on www.english.ids-cologne.de



As an innovative company, NORAKER is not represented in all regions of the world. If you wear an interest in our products, please do not hesitate to contact us.

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