{"id":45,"date":"2020-12-16T10:25:46","date_gmt":"2020-12-16T09:25:46","guid":{"rendered":"https:\/\/noraker.com\/noraker\/?page_id=45"},"modified":"2026-03-19T15:21:23","modified_gmt":"2026-03-19T14:21:23","slug":"verre-bioactif","status":"publish","type":"page","link":"https:\/\/noraker.com\/fr\/verre-bioactif\/","title":{"rendered":"Verre Bioactif"},"content":{"rendered":"\t\t
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VERRE BIOACTIF<\/h1>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Une technologie au service de la r\u00e9g\u00e9n\u00e9ration osseuse<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Les ions alcalins (Na+<\/sup> et Ca2+<\/sup>) sur la surface du verre \u00e9changent rapidement avec des ions d\u2019hydrog\u00e8ne entourant les fluides corporels. La r\u00e9action provoque l\u2019hydrolyse des groupes de silice et induit une augmentation locale de pH et de la pression osmotique.[1-2]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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La silice soluble est transform\u00e9e pour former une couche de gel de silice \u00e0 la surface de GlassBone.\u00a0[3]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Au-dessus de\u00a0GlassBone<\/span>, il se forme une couche d\u2019hydroxyapatite carbonat\u00e9e (HCA) qui est le m\u00eame composant que la couche min\u00e9rale de l\u2019os naturel.\u00a0[4]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Les facteurs de croissance s\u2019adsorbent \u00e0 la surface de\u00a0GlassBone<\/span>\u00a0en raison de ses similitudes structurelles et chimiques avec l\u2019hydroxyapatite. Les facteurs de croissance activent les macrophages M2 afin de favoriser la cicatrisation des plaies et d\u2019initier la migration des cellules prog\u00e9nitrices vers le site.\u00a0[5-6]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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D\u00e9clench\u00e9 par l\u2019activation des macrophages M2, les cellules souches m\u00e9senchymateuses et les cellules ost\u00e9oprog\u00e9nitrices se fixent \u00e0 la surface de GlassBone et se fixent \u00e0 la couche de HCA afin de se diff\u00e9rencier en cellules ost\u00e9og\u00e9niques: les ost\u00e9oblastes.\u00a0[6-7]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Les ost\u00e9oblastes attach\u00e9s et diff\u00e9renci\u00e9s g\u00e9n\u00e8rent et d\u00e9posent des composants de matrice extracellulaire (MEC), principalement du collag\u00e8ne de type I, le principal composant prot\u00e9ique de l\u2019os.\u00a0[7-8]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t

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Suite \u00e0 ces r\u00e9actions, la croissance osseuse se poursuit alors que les cellules nouvellement recrut\u00e9es continuent \u00e0 fonctionner et facilitent la croissance et la r\u00e9paration des tissus.\u00a0GlassBone <\/span>continue \u00e0 se d\u00e9grader et \u00e0 \u00eatre converti en matrice extra cellulaire. [9-10]<\/sup><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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l'histoire<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Le verre bioactif est consid\u00e9r\u00e9 dans le domaine des biomat\u00e9riaux comme l\u2019un des premiers mat\u00e9riaux enti\u00e8rement synth\u00e9tiques qui adh\u00e8re parfaitement \u00e0 l\u2019os. Dans les ann\u00e9es 1960, il a \u00e9t\u00e9 d\u00e9velopp\u00e9 par Larry L. Hench. L\u2019id\u00e9e est venue apr\u00e8s un appel entre Larry Hench et le Colonel Klinker, qui venait de rentrer aux \u00c9tats-Unis apr\u00e8s avoir servi comme officier d\u2019approvisionnement m\u00e9dical au Vietnam.<\/p>\n

Apr\u00e8s avoir \u00e9cout\u00e9 la description des recherches de Hench, le Colonel a demand\u00e9, \u00ab Pouvez-vous faire un mat\u00e9riau compatible avec le corps humain ? \u00bb Klinker ensuite a d\u00e9crit les amputations dont il avait \u00e9t\u00e9 t\u00e9moin au Vietnam. Ces amputations sont le r\u00e9sultat du rejet des implants m\u00e9talliques et plastiques par le corps humain.<\/p>\n

Hench s\u2019est rendu compte qu\u2019il y avait un besoin pour un nouveau mat\u00e9riau qui pourrait former un lien vivant avec les tissus dans le corps. Quand Hench retourna en Floride, il commen\u00e7a \u00e0 synth\u00e9tiser des petits rectangles de ce qu\u2019il appelle du verre 45S5. Ils ont \u00e9t\u00e9 implant\u00e9s dans les f\u00e9murs de rat \u00e0 l\u2019h\u00f4pital VA de Gainesville. Six semaines plus tard les chercheurs ont appel\u00e9 Hench demandant : \u00ab Larry, quels sont ces \u00e9chantillons que tu nous as donn\u00e9 ? Ils restent accroch\u00e9s \u00e0 l\u2019os.
Je les ai tir\u00e9s, je les ai pouss\u00e9s, j\u2019ai craqu\u00e9 l\u2019os et ils sont toujours coll\u00e9s \u00bb.<\/p>\n

Avec cette premi\u00e8re exp\u00e9rience r\u00e9ussie, le verre bioactif est n\u00e9 et les premi\u00e8res compositions ont \u00e9t\u00e9 \u00e9tudi\u00e9. Hench a publi\u00e9 son premier article sur le sujet en 1971 dans Journal of Biomedical Materials Research, et son laboratoire a continu\u00e9 \u00e0 travailler sur le projet durant les dix ann\u00e9es suivantes gr\u00e2ce au financement de l\u2019arm\u00e9e am\u00e9ricaine. Au d\u00e9but du XXIe si\u00e8cle, il y avait plus de 500 articles publi\u00e9s sur le sujet des verres bioactifs de diff\u00e9rents laboratoires et institutions du monde entier. Le laboratoire de science des mat\u00e9riaux Fran\u00e7ais MATEIS, h\u00e9berg\u00e9 dans l\u2019\u00e9tablissement de l\u2019INSA, a d\u00e9velopp\u00e9 une expertise en conception et fabrication de Verre Bioactif 45S5. La soci\u00e9t\u00e9 Noraker a \u00e9t\u00e9 fond\u00e9e en 2005 afin d\u2019industrialiser et d\u00e9velopper ces nouvelles d\u00e9couvertes sur le Bioglass. Depuis, Noraker continue de collaborer avec les meilleures universit\u00e9s europ\u00e9ennes, dans l\u2019objectif non seulement de restaurer les fonctions des patients, mais aussi de r\u00e9g\u00e9n\u00e9rer enti\u00e8rement l\u2019os du patient.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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1 \u2013\u00a0Rahaman, M.\u00a0\u201cBioactive glass in tissue engineering\u201d.\u00a0Acta Biomaterialia.\u00a07<\/strong>: 2355\u20132373.<\/em>
2 \u2013 \u00a0Hench, L.L. (December 2006).\u00a0\u201cThe story of Bioglass\u201d.\u00a0Journal of Materials Science in Medicine.\u00a017<\/strong>: 967\u201378.<\/em>
3 \u2013\u00a0\u00a0Rabiee, S.M.; Nazparvar, N.; Azizian, M.; Vashaee, D.; Tayebi, L. (July 2015). \u201cEffect of ion substitution on properties of bioactive glasses: A review\u201d.\u00a0Ceramics International.\u00a041<\/strong>: 7241\u20137251\u00a0<\/em>
4 \u2013\u00a0Hench, L. L. (July 1998). \u201cBioceramics\u201d.\u00a0Journal of the American Ceramic Society.\u00a0<\/em>
5 \u2013 Roszer, T. \u201cUnderstanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms\u201d.\u00a0Mediators of Inflammation<\/em><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

VERRE BIOACTIF Une technologie au service de la r\u00e9g\u00e9n\u00e9ration osseuse Les ions alcalins (Na+ et Ca2+) sur la surface du verre \u00e9changent rapidement avec des ions d\u2019hydrog\u00e8ne entourant les fluides corporels. La r\u00e9action provoque l\u2019hydrolyse des groupes de silice et induit une augmentation locale de pH et de la pression osmotique.[1-2] La silice soluble est […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"class_list":["post-45","page","type-page","status-publish","hentry"],"yoast_head":"\nVerre Bioactif - 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